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Buprenorphine is also available as a single agent and is used primarily for induction at treatment onset.

As the blockade of exogenous opioids provided by REVIA wanes and eventually dissipates completely, patients who have been treated with REVIA may respond to lower doses of opioids than previously used, just as they would shortly after completing detoxification.

Topiramate to placebo for the treatment for alcohol use disorders.

This begins when the clinician first encounters the patient and notes any obvious sign of pain, such as limping, unusual posture of the body, splinting or guarding, facial expression, and vocalizations.

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