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Binary variables were used for morphometric vertebral fracture, and in the case of missing data on fracture status at 24 months, the data were imputed with the use of the last-observation-carried-forward method.

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Within the AZURE trial, designed to determine whether the addition of ZOL to neoadjuvant therapy improves disease outcomes, a subgroup received neoadjuvant CT.

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However, and depending on many things (including whether you took osteoporosis drugs), a minimum of 6 months is a prudent guess.

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Given that Zol is generally well tolerated and very convenient, it is an interesting therapeutic option for aging patients who take multiple oral drugs, who have adherence or gastrointestinal tolerance issues, and who have an indication for oral bisphosphonates.

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These changes occur within the first week after treatment, as do decreases in serum calcium levels, and are consistent with an antiresorptive pharmacologic action.

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